Abstract: The Eastern Route have been proposed for trans-ferring water from the Chang Jiang to the Tianjin.The Route would use the ancient Grand Canal to transfer water from the Jiangdu Pumping Station in the lower reaches of the Chang Jiang, The Eastern Route of water transfer from Southern would pass through three basin of Huaihe, Huanghe and Haihe. The water would be also pumped to pass through four large lakes, namely,the Hongze, Luoma, Nansi and Dongping.The water pollution of rivers and lakes are very important, because factories of nearby Canal drain waste water that it is coming from industrial pollution source in the Eastern Route of water transfer from Southern. The drained wastewater was mainly from industrial city of three basin and one of them the Haihe basin was polluted more severely than the other two basin.For example, in Haihe basin the over 10×10⁴ tons of drained waste water is in total of twelve city, the drained amount more than 73% of the annual total in this basin. The water quality of Eastern Route would have to be effected by waste water from industrial urban.The natural water quality of surface water is characterized by great varitions in mineralization. South of Huai River mineralization is about 200-300 mg/L mainly by HCO₃^-.-Ca⁺⁺, while in the N of the Huanghe the mineralization increases gradually to 500mg/l, because mineralization of ground water is 500-1000mg/l that it exerts effect on that of rivers.In this paper, we have researched principally also the economical problem of treatmental sewage, lake pollution of Eastern Route and effect on aquatic-economical system from transfered water. Acceding to the analysis of aquatic system in Nansihu lake, an economical analysis method of optimum system is given.