Abstract: The features of the geographical distribution of fluoride in the cultivated soil and the relation between these features and endemic fluorosis were expounded in this paper. The total fluoride in the cultivated soil is mainly affected by the bed rock, or the original rock forming the cultivated soil, so the total fluoride in the cultivated soil in the distribution area of rock and mineral which are rich in fluoride is high. There is an obvious zonality in the geographical distribution of dissoluble fluoride in cultivated soil, it is low in torrid zone and semitorrid zone, most of them are less than 1 ppm; but it is high in arid and semi-arid region of temperate zone and semi-temperate zone, most of them ane more than 2 PPm. The effect of both the total fluoride and dissoluble fluoride in the cutivated soil on the fluoride content in food crops is not obious, however there is a close relation between the dissoluble fluoride in the cultivated soil and fluoride in shallow ground water.Thus the effect of cultivated soil on human body for resulting in fluo-orosis is by way of the affecting fluoride in shallow ground water which is used as the source of the drink water.