This paper analyzes the causes of the development of the economy in the Region of Huaiyin which is slower than in the South of Jiangsu Province from the point of view of Cultural Geography,and indicates that the low level of culture development,being one of the major causes,has kept the Region of Huaiyin being left behind the Southern Jiangsu Province in the modern and contemporary economy.The Region of Huaiyin is characterixed by the closed and transitional geographical environment and the self-sufficient farmitig economy.All these factors result in conservativeness and exclusiveness of the culture of the Northern Jiangsu Province.Huaiyin Region has got the traditional agricultural culture as its main cultural component,and its science,technology and education are at a low level.such poorly developed culture can be nothing but a hindrance to the people's acceptance of fresh knowledge,modern and advanced science and civilization,Thus it forms a block on the way of the economical development of the Region of Huaiyin.