Based on the study of genetic mechanism of earthquake disaster,the seismic intensity,population density,per unit area total product values of industry and agriculture were selecteas the indicative factors. According to the date from the 50 earthquake examples,a regression equation among the personal injury,economic loss and above factors have been established, which is used for the macroscopic evaluation of regional earthquake disasters. In thetests by using it in the other two seismic samples,the results can satisfy the requirements formacroscopic analyses. It proves that the method can reduce the dependence upon the historical information about earthquake disasters,and promote the depth and accuracy of the research on disastrous regional differentiations.