The knowledge-based economy will gradually dominate world economy in the coming knowledge economy age. The advantages and characteristics of geographical comprehensive study will contributed to opening up new research fields due to the common ground with the characteristics of knowledge economy such as sustainability of economic development, innovation of knowledge and globalization of world economy. To adapt itself to the new conditions, however, it is necessary for geographical comprehensive study to innovate the research contents, including paying more attention to mutual substitution among the resources and elements of production owing to scientific and technological development, fully considering the signficance of virtual geographical space to geographical comprehensive study, changing the traditional notion of elements-balanced in geographical comprehensive study, and giving up dualistic system fram (i.e. regards natural factors and socioeconomic factors as different systems).