The regional development research and decision making are the metasynthetic engineering.According to the idea of Hall for Workshop of Metasynthetic Engineering (HWME) advanced by Qian Xuesen,this article puts forward a framework of HWME for regional sustainable development (HWME RSD).The HWME RSD combines the modern computer technology,decision making technology and traditional system engineering technology.The HWME RSD may be considered from two aspects:(1) As a huge intelligent system,the HWME RSD can be built as a physical system partly or entirely;(2) As a methodology,the HWME RSD is a series of logical processes that organize the researchers and available tools together to solve problems more effectively.The word "HALL" of HWME RSD stands for a computer network supporting environment that can be regarded as a "virtual hall" or a "logical hall".