The adjustment of the administrative division can lead to the change in the spatial structure of the urban area, which exerts great influence on the regional social, economic, political and cultural development.In July, 2011, the State Council approved to annul Chaohu city and divided it into three parts which was respectively incorporated into the jurisdiction of Hefei, Wuhu and Ma'anshan.The adjustment of the administrative division provides the development space of Hefei, and eliminates the barrier of integration of Wuhu south and north of the Yangtze River.Thus the two core cities of Hefei and Wuhu are adjacent to each other.There exists an obvious dual core structure in regional space, and the economic regions are more directly connected.Dual core structure of Hefei and Wuhu is the typical regional spatial structure in Anhui.Dual core development mode, driven by Hefei economic circle with Hefei as its core, and Wanjiang city belt with Wuhu as its core, is an inevitable requirement of Anhui economic development, its spatial integration has some favorable conditions, including adjacent endpoints of urban space, advantages of integration strength, increasingly great leading role, advantageous internal and external environment of“sector of Hefei, Ma'anshan, Wuhu and Tongling” and Nanjing metropolis circle.It is faced with new development opportunities, different development modes and routes are chosen for different periods.With employment of the city space interaction theory and methods and dual core structure principle, the paper analyzes the dual core spatial integration of Hefei-Wuhu after the adjustment of the administrative division, and presents the following measures including adopting axis mode, dual core mode, “T” mode, sector mode in different periods, removal of rigid restraint of the administrative districts, strengthening integrated planning of dual core axis, enlarging industrial integration, bringing into full play the comparative advantages of the city between dual cores, and overall advancement of development axis construction of Hefei-Wuhu.According to central place theory, strengthening the dual core spatial integration of Hefei-Wuhu and cultivating a core growth pole leading the development of Anhui play a critical role in Anhui economic development, especially for Chaohu economic valley in Wanjiang city belt.