With the adoption of "National Planning for the Major Function Oriented Zone (NMFOZ)" by the Chinese central government in 2010,the implementation of this planning will be a core task in the following and future years.In the implementing era,the work of monitoring and evaluating the status and development trend of NMFOZs,which include their physical,ecological,social and economic elements at regional and national levels,is one of basic approaches to grasp the practical information and adjust the operational status for those NMFOZs.According to the basic requirements and spatial features of NMFOZ,based on the integration between modern geographic information technology and traditional statistic technology,a comprehensive framework including a series of spatial indices was put forward, including 2 levels,9 groups and 60 concrete indexes.At the top level,9 index groups,including resources,environment,ecology,natural hazards,economy,population and society,policy, communication and NMFOZ operating system,were organized firstly.Then at the lower level, each index group was further decomposed into a series of distinctive operational indexes that can be easily obtained or integrated from the remote sensing information and traditional economic&social surveys and statistics.For example,the population and society index group covers 7 concrete indexes,i.e.total population,population inflow ratio,population outflow ratio, ratio of non-agriculture population,poor population,R&D ratio,and energy consume per unit GDP.The entire index listed here can be further calculated,analyzed and visualized by the assistance of geographic information system(GIS).Finally,the authors discussed the completeness and practical applicability of the spatial indexes,index data acquisition methods, data processing methods and expression methods.Although some shortcomings exist in the presented index framework,there is no doubt that our results offer a reference for the future monitoring and evaluating work.