Studies on land use change play one of the most important parts in LUCC, which focus on the change of land use structure, pattern and its rate, ecological effect and so on. This paper takes Shenzhen City as a case based on RS and the GIS. Several remote sense images, land use data of status quo, and landform data during 1978~2001 are used to analyze the time-space differentiation of land use change, so as to study the influence of city landform on the land use. The landform is an important influencing factor of land use change in cities. Because various land use types are all placed in certain vertical space, the change of land use will cause the variation of vertical barycenter. The data analysis shows that, the arable land was the most unstable, 609.76 km² of which changed into other types during the 23 years, while its vertical barycenter declined. However, the areas of construction land increased by 579.20 km², and its vertical barycenter increased by 6.49 meters during this period. The increasing trend of woodland's barycenter was more stable than that of construction land, and the transferred area ratio was the lowest among all types of land use. The restriction of landform to the land use dynamics is obvious in Shenzhen for the land use dynamics degree decreases with the increase of the elevation and slope, the dynamics index on the same elevation belt and slope belt gradient presented an increasing trend during the urbanization process. According to the curve of the land use dynamics state, during the natural landscape period, the agriculture-developed period and the post-urbanization period, the land use dynamics indexes on elevation belts and slope belts are stable and low. Even in the low plane region, the dynamics curves are close to zero. Between these three periods are the agriculture-developing period and rapid-urbanization period, whose land use dynamics indexes are higher. In a word, the index shows a spiral rise, but the dynamics of these five periods show a common trend that it is getting lower with the increase of elevation and slope.