The formation and development process of urban agglomeration is the integration and optimization evolvement process of its spatial structure; it is also the reorganization and optimization process of its industrial structure. Researching the well-spatial integration and organization can strengthen industrial cooperation and structural inter-reinforce among cities; which is helpful to seek the optimal industrial competition and cooperation road for urban agglomeration in the process of economic globalization and regional economic integration. Wuhan Urban Agglomeration which lies in the middle economic hinterland in Central China is the bridge and bond of industrial gradient shift from east to west, also the important strategic pivot in the rising of Central China. Based on the analysis of the strategic status of Wuhan Urban Agglomeration, this paper proposes the overall thinking of constructing ecological urban agglomeration, confirm its overall orientation as the important engine of region economic growth, the pivot of interactive development among the eastern, western and middle parts which take the Yangtze River economic belt as the main axis and important center of the advanced manufacturing and service industries in central region; puts forwards the node-axes structure scheme which is composed of "One Core" (Wuhan main core), "Two Rings" (the freeway outer ring circling Wuhan urban district and the expectant freeway outer ring circling Wuhan Urban Agglomeration), "Two Belts" (two eco-barriers which consist of Tongbai-Dabie Mountain in northeast and Mufu Mountain in south), and "Four Axes (four-city and industrial development belts); the circle structure scheme which is composed of core circle, close circle and radiation circle; the cluster structure scheme which is made up of Huangshi-Ezhou-Huanggang eastern industry-city cluster, Xiantao-Qianjiang-Tianmen western industry-city cluster, Xiaogan-Hanchuan-Yingcheng northwestern industry-city cluster and Xianning-Chibi-Jiayu northern industry-city cluster; the spatial morphology structure scheme which is made up of "One Main Center"(metropolis city Wuhan), "One Sub-Center"(super-large cities compositing with Huangshi urban district and Daye urban district), and Seven Nodes (Huanggang urban district, Xiaogan urban district, Ezhou urban district, Xiantao urban district, Qianjiang urban district, Xianning urban district, and Tianmen urban district). Finally, the paper proposes the thoughts on industrial development and contribution including extending the 10 preponderant industrial chains such as automobile industry, opto-electronic industry, iron and steel industry, nonferrous metallurgy industry, petrochemical industry, salt chemical industry, textile and apparel industry, papermaking and packaging industry, construction industry, agricultural by-products industry, constructing 15 industrial clusters and seven characteristic industrial belts which are of important interregional significance, furthermore making the distribution and corporation scheme of industrial development.This paper has the strategic significance and important realistic meaning to the development of Wuhan Urban Agglomeration, Hubei Province and rise of Central Rise China, it is an important guidance for enriching and perfecting the theory of spatial integration and industrial optimization for urban agglomeration, and also providing references to other urban agglomerations in China on achieving the spatial integration and industrial optimization.