The Western Long Hai-Lan Xin Economic Zone is an important part of the "two zones and one district" in the great strategic development of western China. The authors analyze the overall characteristics of the node cities along the Western Long Hai-Lan Xin Economic Zone, and considers that though the cities are distributed concentratively and the urbanization level is higher than that of the western region and the whole country, yet the metropolises are far away from each other and no big cities lying between them. So three weak zones come into being along the Western Long Hai-Lan Xin Economic Zone and the cities' spatial distribution of "point-axis" type will still exist. According to multi-hierarchical and multi-target comprehensive measurement model, all the cities' comprehensive competitiveness along the zone is evaluated. Xi'an,Lanzhou and Urumqi are considered as the first class node cities along the zone and Xianyang,Jiayuguan,Baoji,Jiuquan,Karamay,Hami,Shihezi,Korla,Tianshui and Kuytun are considered as the second class node cities along the zone. Based on this, the development orientation and the industrial division of the node cities along the Western Long Hai-Lan Xin Economic Zone are put forward. Xi'an-Xianyang metropolitan district is considered as the first class key node city in western China and the east of the Western Long Hai-Lan Xin Economic Zone, which should be constructed as the core of the Guanzhong Economic District and Guanzhong New High-tech Industrial Development Zone. Lanzhou-Baiyin metropolitan district is considered as the first class subordinate node city in western China and the first class key node city in the middle section of the Western Long Hai-Lan Xin Economic Zone, which should be constructed as the core of the multi-nationality economic zone in the upper reaches of the Yellow River. Urumqi-Changji-Miquan-Fukang metropolitan district is considered as the second class key node city in western China and the first class key node city in the western section of the Western Long Hai-Lan Xin Economic Zone, which should be constructed as the core of the northern Tianshan Mountain economic zone. Baoji,Tianshui,Jiuquan-Jiayuguan-Yumen,Hami,Kuytun-Dushanzi-Usu are considered as the second class subordinate node cities in western China and the first class subordinate node cities in the Western Long Hai-Lan Xin Economic Zone, which should be constructed as the five “piers” in the weak zones of the continental bridge to support the whole economic zone.