In regional economic development, the profit-making enterprise is the microcosmic basis. So it is full of vigor in market-economy. The author thinks that the coordinated process of regional economy is actually the operational process of regional economy of the profit-making enterprises. It means that only through the circulation of resources,fund and commodities among these enterprises, can the regional economy achieve coordination. On the basis of economic location and lots of statistical data, this paper researches the models and ways about enterprises spatial effect, which is the microcosmic mechanism of the regional economic coordination, for the purpose of making regional economy achieve marketablization, and regional economic coordinated and healthy development. In this paper the authors analyzed the leading industries in the cities of Wuhan,Shiyan and Xiangfan and came to the conclusion:(1)from Shiyan to Huangshi the metallurgical and engineering industries take the lead and are stretching to Henan and Jiangxi provinces;(2)Shashi and Xiangfan are the cores of textile industry, they will become stronger and stronger and will eventually unite as one.