Conducting the soil geochemical survey, and accessing the distribution and driving mechanisms of soil geochemical parameters are of great significance for eco-environment condition evaluation and the land resources management. Based on the soil geochemical survey in the Xiong'an New Area, a combination of spatial analysis and multivariate statistical analysis was used to study the spatial distribution patterns of soil elements, and discuss the driving mechanisms of these elements. The result showed that most elements were enriched in soils of the study area compared with their background values of Hebei plain. The concentrations of Cd, Cu, Pb, Zn, Se, and Corg in soils were 1.16-1.44 times higher than their background values of Hebei plain. Most elements were principally concentrated in the alluvial lacustrine plain, which was mainly determined by the parent materials, landform types, and weathering and leaching processes. Anthropogenic factors such as land utilization and industrial and agricultural activities significantly influenced natural evolution of heavy metals and nutrients elements in soils in the study area. Eight factors were extracted to represent different driving mechanisms of soil elements distribution. F1, mainly consisting of lithosphere and siderophile elements and rare earth elements, represented pedogenesis process. F2, composed of heavy metal elements, was associated with anthropogenic activities such as sewage irrigation and industrial production. F3, made up of CaO, TC, Ge, Ti, and SiO2, was related with the processes of silicate mineral weathering and secondary carbonate formation. F4, comprised of Cl, S, and pH, had a close relationship with the processes of leaching and surface runoff, and evaporation and concentration. Meanwhile, land utilization also exerted an influence on the distribution of these elements. F5, composed of soil nutrients elements, was mainly affected by anthropogenic activities such as land utilization and agricultural activities. F6, principally including B and Sr, illustrated the adsorption reactions with soil clays. F7, made up of I and Br, reflected surface runoff process. F8, including Hg, was correlated with anthropogenic emissions such as coal combustion and smelting activities. The result of this study clearly uncovered the geochemical characteristics of soil elements and its driving mechanisms in the Xiong'an New Area, which would provide valuable information for rational land resources utilization and environmental protection in the study area.